| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 6
| Issue : 1 | Page : 7-16 |
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COVID-19 associated acute kidney injury in the second wave of pandemic in India: A single-center retrospective report
Subho Banerjee, Ruchir Dave, Hari Shankar Meshram, Sanshriti Chauhan, Vivek B Kute, Himanshu V Patel, Sudeep Desai, Priyash Tambi, Nauka Shah, Akash Shah
Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Centre, Dr. Hl Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India
Correspondence Address:
Hari Shankar Meshram
Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Centre, Dr. Hl Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/sccj.sccj_32_21
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Introduction: Acute kidney injury (AKI) in coronavirus disease (COVID-19) is understudied, especially after the initial pandemic wave and in South East Asian Region. Materials and Methods: This was a single-center retrospective cohort of 856 hospitalized COVID-19 cases between March 26, 2021, and June 7, 2021 in India to study the spectrum of AKI in COVID-19. The primary outcome was to analyze predictors of AKI. Other secondary outcome measured was mortality in AKI. Results: The incidence of AKI was 38.1%. The incidence of hemodialysis requirement was 3.5%. The proportion of AKI I, II, and III was 80.2%, 8.2%, and 11.6%, respectively. The mortality in AKI was statistically significantly higher than in non-AKI compared to AKI. Among the laboratory markers, the highest area under the curve (AUC) in the receiver operator curve was reached for red cell distribution width [AUC = 0.77 (0.73–0.81); P < 0.01]. The predictors for AKI calculated by multivariable logistic regression model in the cohort were obesity (hazard ratio (HR) = 3.2 (1.08–9.73); P = 0.04) and baseline European Cooperative Oncology Group (ECOG ≥ 3) (HR = 3.4 (1.77–6.69); P < 0.01). Similarly, the risk factors for developing AKI III included male sex (HR = 1.33 (1.05–1.68); P = 0.02) and ECOG ≥ 3 (HR = 1.5 [1.18–1.9]; P < 0.01). Conclusion: The incidence of AKI is high in hospitalized patients in the COVID-19 second wave. The mortality associated with AKI remains high. The comorbidity burden was not linked with AKI.
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